Monitoring the environment for pollution, pesticides, and pathogens is crucial for protecting human, agriculture, and overall ecosystem health.Diverse strategies ranging from physical sensors to sentinel species have been used for environmental monitoring.The European honey bee, Apis mellifera, is a globally managed pollinator that can serve as a c
The yeast Geotrichum candidum encodes functional lytic polysaccharide monooxygenases
Abstract Background Lytic polysaccharide monooxygenases (LPMOs) are a class of powerful oxidative enzymes that have revolutionized our understanding of lignocellulose degradation.Fungal LPMOs of the AA9 family target cellulose and hemicelluloses.AA9 LPMO-coding genes have been identified across a wide range of fungal saprotrophs (Ascomycotina, Basi
A Rate of Change and Center of Gravity Approach to Calculating Composite Indicator Thresholds: Moving from an Empirical to a Theoretical Perspective
A composite indicator (CI) is the mathematical aggregation of sub-dimension (local) indicators used to provide an overall score for the multidimensional concept being measured.CIs are widely used to assess the benefits or risks in human endeavors, such as by creating life satisfaction indices or disaster risk indicators.One important aspect of the
Nef-Mediated CD3-TCR Downmodulation Dampens Acute Inflammation and Promotes SIV Immune Evasion
Summary: The inability of Nef to downmodulate the CD3-T cell receptor (TCR) complex distinguishes HIV-1 from other primate lentiviruses and may contribute to its high virulence.However, the role of this Nef function in virus-mediated immune activation and pathogenicity remains speculative.Here, we selectively disrupted this Nef activity in SIVmac23
Adoption of 37mm Maxim Automatic Guns by Russian Navy in Late 19th to Early 20th Century
This study Course a pied - Homme - Chaussures - Neutre investigates the adoption of Maxim automatic guns by the Russian Navy during the late 19th and early 20th centuries.It explores the close relationship between this topic and the development of naval artillery in Russia, as well as the dynamics of the domestic military-industrial complex and the